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To determine whether GSSG-induced TNF hepatotoxicity is associated with inhibition of the NF-B signaling pathway, we first examined the effects of H 2 O 2 , BCNU, and diamide treatment on TNF-stimulated NF-B activation

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An estimated ~1100 nuclear-encoded proteins are required for mitochondria-specific pathways in a tissue- and cell-type specific manner, with nuclear and mitochondrial OXPHOS subunits requiring strict coordination and stoichiometric expression 6

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