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Isnt the statement .with no malice aforethought akin to saying I dont wish to be rude, but. Why make a point of such a statement when the irony is that the whole study is designed to cut down on perceived (and not scientifically backed up) excess treatment which served to harm patients and did not, by any stretch of the imagination prevent illness

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It then passes through the livers portal vein, finally reaching the systemic circulation