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Furthermore, the NLRP3 inflammasome and cyclic GMP-AMP synthase-STING pathway, which are associated with increased mitochondrial damage and respiratory stress, are activated in MS (133,134)

Qiu et al., 2018), CCl4 (Teraoka et al., 2012

Primary research: Mitochondrial dysfunction, Barth syndrome, heart failure, age-related mitochondrial decline Mechanism: Binds cardiolipin in the inner mitochondrial membrane, stabilizing electron transport chain function and reducing reactive oxygen species Regulatory status: FDA-approved (Forzinity) for Barth syndrome

Insulin concentration was determined according to manufacturer protocol

Schilling test The Schilling test is performed to evaluate vitamin B12 absorption

Guo Z, Xie W, Lu J, Guo X, Xu J, Xu W, Chi Y, Takuya N, Wu H, Zhao L (2021) Tannic acid-based metal phenolic networks for bio-applications: a review