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After a week, a small difference so upped to to 350mcg for 2 weeks and had a better response then went up to 400mcg and that was our sweet spot

Phytochem Rev 116 Kimble R, Keane KM, Lodge JK, et al (2022) Polyphenol-rich tart cherries (Prunus cerasus, cv Montmorency) improve sustained attention, feelings of alertness and mental fatigue and influence the plasma metabolome in middle-aged adults: a randomised, placebo-controlled trial

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Even small amounts of selenium are sufficient for correct DIO activity, but a reduced selenium intake affects GPx expression and function, leading to impaired antioxidant activity in thyroid cells

Many people find this to be a step up from standard reduced glutathione, though it still lacks the protective "shell" found in liposomal versions