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LPS induces the tetramerization of PKM2 leading to decrease its nuclear localization and the expression of glycolytic and HIF-1-induced genes

Certain phospholipids enriched in the inner mitochondrial membrane, such as phosphatidylcholine (PC), PE, and cardiolipin (CL), are essential for maintaining membrane integrity, stabilizing membrane proteins, shaping cristae structure, and facilitating OXPHOS assembly [205]

Future studies are likely to explore additional combination therapies, particularly those involving drugs with distinct mechanisms of action, such as pairing iron chelators with antioxidants or mitochondrial protectants (64)

Groundnut has certain nutrients which can be helpful for kidney patients

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Nevertheless, the cytoprotective effect of LDHA overexpression can be counteracted by vascular endothelial growth factor A (VEGFA)