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Like other organs, the nervous system is composed of specific cell types with distinct metabolic needs and characteristics, which can lead to mitochondrial heterogeneity (Rangaraju et al., 2019

However, there are several issues with FMT as follows: biological mechanisms remain undescribed, donor stool will not always be available, risks and side effects remain unclear, and long-term safety data are extremely limited (Liu Y

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The results from the study on the prodrugs impact on tumor growth in A549 xenografts show that it is more effective at inhibiting tumor growth in vivo than the unmodified 5-FU compound (Figure 5C)

Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

This process is further amplified by the lipid-rich TME, where CD36 upregulation on CD8 T cells is correlated with increased expression of the exhaustion markers PD-1, TIM-3, and LAG-3 [53]