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To uncover the root-specific biochemical adaptations behind this remarkable resilience, researchers performed untargeted metabolomics profiling of both O

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27 Consistent with the lack of mitochondrial involvement, erastin did not cause ATP depletion, and morphologically, mitochondria appeared smaller and denser, but not swollen or ruptured as seen in classical necrotic cell death

Antioxidants are essential to prevent the formation and oppose the actions of reactive oxygen and nitrogen species, which are generated in vivo and cause damage to DNA, lipids, proteins, and other biomolecules