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Blood biomarkers Circulating biomarkers provide the opportunity to characterise metabolic derangement, collagen turnover as well inflammatory and immune activation (Rubis et al., Reference Rubis, Dziewiecka, Wisniowska-Smialek, Banys, Urbanczyk-Zawadzka, Krupinski, Mielnik, Karabinowska and Garlitski2022)

Moreover, in human Caelyx PC, the main proteins found were immunoglobulins, fibrinogen, albumin, apolipoproteins, and, to a lesser extent, some complement factors

36,38,237,238,239 The E-boxes in the promoter of Nampt gene allow the direct transcriptional control by the CLOCK: BMAL1 chromatin complex

Lin C, Sang Q, Fu Z, Yang S, Zhang M, Zhang H, et al

doi: 10.1017/S0007114524001405 182

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