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If double-strand breaks are not properly repaired or are misrepaired, they can result in chromosomal instability, cell death, and the incidence of cancer (Chiorcea-Paquim 2022)

It is involved in the signaling for survival and transcription through associations with the Egr-1 transcription factor and Akt/PI3K cell survival pathway

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doi:10.1089/ars.2010.3496, PMID: 20673163 Yan Z, Banerjee R (2010) Redox remodeling as an immunoregulatory strategy

Previously it has been reported that curcumin as an anti-oxidant reduce gene and protein expression of KIM-1 and NGAL and alleviate oxidative toxic stress in the kidney tissue of type 1 diabetes rats [17]

Cisplatin-induced apoptosis in rat dorsal root ganglion neurons is associated with attempted entry into the cell cycle