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Furthermore, spinal caspase-3 cleavage is required for axonal degeneration, mitochondrial dysfunction, oxidative stress and apoptosis in the pathogenesis of CIPN after intraperitoneal vincristine stimulation in mice (Yu et al., 2021)

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Hence, it is vital to correctly determine whether ferroptosis exerts an anti- or pro-inflammatory effect on inflammation

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pseudomallei , especially from direct clinical specimens, in order to initiate antibiotic treatment to prevent relapse and reduce the mortality rate

3,4 Latent TGF-s are activated by various pathways in vivo Although TGF- ligand and receptors are ubiquitous in many types of cells, their biological effects are usually restricted at sites where the ligand is activated