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Disclosure of interest: Marc Rib: nothing to disclose

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This leads to the release and cytoplasmic translocation of p53, which can subsequently activate transcription-independent pro-apoptotic signaling (Clara et al., 2024

For the research context it is key for understanding why amylin analogs do not develop tolerance with chronic use (unlike many other anti-obesity molecules)

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It's present in blood plasma, saliva and urine, with levels peaking around age 20 and declining significantly by 60