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As we age, collagen production naturally declines, leading to visible signs of aging such as wrinkles, sagging skin, and joint discomfort

This is important, because we now recognize that the buildup of mitochondrial waste products is one of the most important contributors to insulin resistance, which further promotes high blood sugar and obesity

Summary Keywords Leigh syndrome, mitochondria, respiratory chain complex, mitochondrial DNA, mitochondrial genetics Citation Bakare AB, Lesnefsky EJ and Iyer S (2021) Leigh Syndrome: A Tale of Two Genomes