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Wang C, Li P, Xuan J, Zhu C, Liu J, Shan L, et al

However, the expression of GPx1 has been reported to be down-regulated in thyroid cancer [44], colorectal cancer [45, 46], and gastric cancer [47], whereas GPx1 has been demonstrated to play an oncogenic role in kidney cancer [48], pancreatic cancer [49], and laryngeal squamous cell carcinoma [50]

For instance, lactylation of adenylate kinase 2 at the K28 site has been found to inhibit its function, thereby facilitating proliferation and metastasis in hepatitis B virus-related hepatocellular carcinoma cells [21]

This finding strongly suggested that bioenergy metabolism of tumor had an obvious reprogramming after engraftment from patients to mice, and the glycolysis in PDXG1 was suppressed, leading to a shortage of pyruvate and its downstream metabolites

10.3390/ijms20010117 [DOI] [PMC free article] [PubMed] [Google Scholar] 7.Adin CA, VanGundy ZC, Papenfuss TL, Xu F, Ghanem M, Lakey J, et al