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Besides Ca 2+ , aromatic L amino acids (L-Trp, L-Phe) also activate the CaSR by binding adjacent to the VFT region through three serine and one threonine residue (S169/S170/S171/T145)

doi: 10.1016/j.seizure.2018.11.010 31

In animal studies, the peptide has been well tolerated at standard research doses

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BPC-157 Oral Dosage: When Troches or Capsules Make Clinical Sense Oral BPC-157 is preferred for gastrointestinal indications including leaky gut, inflammatory bowel conditions, and systemic anti-inflammatory support where localized injection is not the primary target

Most of these ingredients have been studied when taken orally, and their effects when delivered through the skin are not well understood