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Platelet phenolsulfotransferase and catecholamines: physiological and pathological variations in humans

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These effects of Pycnogenol on joints can be explained by previous findings, showing that regular intake of Pycnogenol leads to a potent decrease of pro-inflammatory markers like NF-B and COX-enzymes, as well as a decline in the release of matrix metallopeptidase (MMP) enzymes, that are responsible for destroying cartilage in joints (1518, 71)

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There was a significant drug x days interaction (F = 1.76, p = 0.006) but no significant drug x trial (F = 0.33, p = 0.92) or trial x days interaction (F = 1.25, p = 0.20)

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