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However, its clinical application is limited owing to oral toxicity, gastrointestinal toxicity, leukopenia and thrombocytopenia (75)

At the ovarian level, receptor-mediated uptake and intracellular handling further favor DHA incorporation into the granular yolk layer, where it accumulates predominantly within phospholipid fractions

However, the role of AMPK has been challenged and might only account for indirect changes in hepatic insulin sensitivity

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Their modulation of the SIRT1/Nrf2/KEAP1 pathway along with reduced DNA fragmentation, has been observed to preserve renal histology when used as therapeutics against chromium and arsenic-induced nephrotoxicity