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Dietary fructose is converted by the gut microbiota to acetate which is taken up by the liver and irreversibly catalyzed to acetyl-CoA by the hepatic cytosolic enzyme ACSS2 [188]

ConcentrationAdverse Reaction Relationships There is a relationship between increasing hydrocodone plasma concentration and increasing frequency of dose- related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression

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