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Overall, these results were consistent with NTSR blackgrass having an enhanced capacity to metabolise MCB to its fluorescent conjugate GS-B and accumulate the metabolite in vivo as compared with HS plants and that this process was energy dependent as a consequence of the associated ABC transporter activity

Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events

Mansell JB

Without adequate B12, these vital processes falter, and fatigue is often one of the earliest and most noticeable symptoms

This exaggerated response can emanate from stimuli of similar (i.e., microbial antigens) or different stimuli (including inflammatory, metabolic, oxidative or nitrosative stress) (Salter and Beggs, 2014

The pain can be brief but intense and often occurs in episodes that last seconds to minutes, sometimes repeatedly throughout the day