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doi: 10.3168/jds.2021-20284 197 NelsonCDReinhardtTABeitzDCLippolisJD

In cancer cell lines, the mTORC1 signal can also promote de novo lipid synthesis through the sterol responsive element-binding protein (SREBP) transcription factors, which induce the expression of metabolic genes responsible for lipid biosynthesis, including fatty acid synthase (FASN) (Duvel et al., 2010)

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Beyond these classical mechanisms, bilirubin may fundamentally shape PD risk by orchestrating early embryonic development of dopaminergic neurons through key morphogenic signals, thereby ensuring robust neural circuit formation