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NNMT has been explored as a target in obesity, insulin resistance, and age-related metabolic decline, supporting the rationale for translational research into body composition and performance contexts (Kannt & Pfenninger, Frontiers in Physiology )

The heading of cardiac included patients with diagnosis and having been medically treated for hypertension (HTN), hypercholesterolemia, arrhythmia, congestive heart failure (CHF) or had a history of myocardial infarction (MI)

Most manufacturers recommend refrigeration at 2-8C even for unopened vials, though some formulations remain stable at room temperature for short periods