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It creates a chronic pro-oxidant environment that overwhelms the already-depleted GSH-based antioxidant network in diabetic patients

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Following near-total ablation of -cells in mice, -cells can transform into bihormonal (insulin + /glucagon + ) cells and subsequently into monohormonal insulin + cells (Thorel et al., 2010)

He XF, Lu Z, Ma B, Zhang L, Li JL, Jiang Y, et al

All GSH measures and time to deproteinization were log-transformed to meet assumptions of linear models (homogeneity of variance, normality of error, and linearity) [32]

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