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Technical and biological hurdles are paramount, including the inefficient delivery of cells or vectors to widespread motor neurons across the central nervous system, host immune responses that can limit efficacy or durability, and unresolved long-term safety concerns such as off-target effects or uncontrolled cell differentiation (15, 60, 65)

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Glutamine metabolism regulates oxidative stress by regulating glutathione synthesis (145)

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The research has found that the glycosaminoglycan (GAG) biosynthesis genes XYLT2 , B3GALT6 , and B3GALT3 are crucial for the sensitivity of candidalysin (Lin et al., 2024)