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Glutathione as a reducing agent in cytoplasm is important in imparting antioxidative properties to the bacteria

Curr Drug Targ 21(13):13851393 Assis VL, Veras AC, Maciel PM, Albuquerque JG, Zancanella C, Ritto JL, Arajo IGA, Veras RC, Medeiros IA (2020) Effects of Funchicrea, a traditional brazilian herbal complex, on intestinal motility in healthy and constipated rodents

To determine how APR-246 depletes GSH, we applied mass spectrometry to show that 2-methylenequinuclidin-3-one (MQ), the active component of APR-246, reacts with GSH inside cancer cells (Fig