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Description

Medication alone cannot overcome certain behavioral and environmental factors that influence metabolic health

6:e13799

Tate, V

Cells were fixed with 4% paraformaldehyde in PBS for 30 min and washed with PBS Ca 2+ /Mg 2+ (Sigma-Aldrich)

Similarly, pharmacological inhibition of GPX4 by Ras-selective lethal compound 3 (RSL3) blocks the enzymatic detoxification of lipid hydroperoxides, resulting in excessive lipid peroxidation and ferroptotic cell death [56,57,58] (Fig