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Finally, using transcription factor motif analysis, we observed that there is more than one binding site motif for ATF4 in the upstream promoter (approximately 1000 bp upstream of the transcription start site) regions of GPX4 , GSS , NFE2L2 , ATG3 , ATG4D , and other genes, and all the sites have the [TGACGTGGC(A/G)] basic motif sequence (Figure 5E)

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BP@CeO x showed the same three characteristic Raman peaks of BP nanosheets, which were ascribed to one out-of-plane phonon mode ( A 1 g ) at 363 cm -1 , and two in-plane modes ( B 2g and A 2 g ) at 439 and 467 cm -1 , respectively, suggesting that the combination of CeO x did not cause the structural transformation of pure BP

Mitochondria, as central hubs of cellular energy metabolism, dynamically integrate calcium signaling, lipid exchange, redox homeostasis, and gene regulation through membrane contact sites with the endoplasmic reticulum (ER), lysosomes, peroxisomes, lipid droplets, and the nucleus [22]

They increase the levels of dopamine and norepinephrine, which are neurotransmitters (brain chemicals) involved in reward and motivation