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Neggers et al., confirmed these observations, highlighting that over 70% of children affected by ASD showed positivity to these autoantibodies and may benefit from targeted folinic acid supplementation (Neggers, 2014

Drugs Tightly Bound to Plasma Proteins Because fluoxetine is tightly bound to plasma protein, the administration of fluoxetine to a patient taking another drug that is tightly bound to protein (e.g., Coumadin, digitoxin) may cause a shift in plasma concentrations potentially resulting in an adverse effect [see Clinical Pharmacology (12.3)]

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PMID: 8263160