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doi: 10.1002/clt2.12283, 119

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Oxidative stress increases the accumulation of free radicals and activates signaling pathways such as MAPK and NF-B, promoting the production of pro-inflammatory cytokines (196)

The hypothesis posits that diminished glutamatergic activity within the medial prefrontal cortex (mPFC) directly influences depressive behaviors, substantiated by evidence derived from both preclinical and clinical investigations