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In clinical trials, Ipamorelin was well tolerated, with no significant effects on prolactin or cortisol secretion compared to other GHRPs. van den Berghe et al., The Journal of Clinical Endocrinology & Metabolism Rare or Potential Concerns Injection site irritation (especially with poor reconstitution technique) Overstimulation of GH axis with excessive dosing or stacking GH-related side effects at high doses (e.g., mild carpal tunnel, joint tightness) These are more likely in unsupervised high-dose or long-term protocols , especially when paired with additional GH-enhancing compounds

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Food & Drug Administration (2025) Your guide to FDA-approved medicines that contain semaglutide, Novo Nordisk FDA alerts health care providers, compounders and patients of dosing errors associated with compounded injectable semaglutide products, U.S

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