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Older people, at a time when OA becomes more prevalent, decrease their food intake often at the expense of proteins, frequently due to economic concerns

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Nevertheless, the presence of the BBB hampers the uptake of many PD drugs by the brain, compromising their therapeutic efficacy

Beyond their well-known response to local neuronal activity, we hypothesize that circulating hormones like ghrelin (hunger signal) and leptin (satiety signal) directly bind to receptors on hypothalamic astrocytes

These signaling molecules can then modulate many downstream effectors through various mechanisms to alter synaptic strength

Pure compounds from Moringa extract improve insulin secretion in the pancreatic islets of mice