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Neurotrophic Factor Delivery (top right, orange): Administration of trophic molecules like BDNF and CDNF, either via receptor activation (e.g., TrkB) or exosome-based delivery, promotes neuronal survival, synaptic stability, and overall network resilience

Otte C, Gold SM, Penninx BW, Pariante CM, Etkin A, Fava M

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They found that gut microbiota changes, particularly the influence of Desulfovibrio and Akkermansia, along with disturbances in lipid metabolic pathways in the prefrontal cortex and hippocampus, led to the manifestation of atherosclerosis combined with depressive symptoms in the mice (172)

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