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J Biol Chem 282:2947081, PMID: 17690092 Franco R, Cidlowski JA (2009) Apoptosis and glutathione: beyond an antioxidant

Deficiency in either produces hyperhomocysteinaemia, an independent risk factor for cardiovascular disease, cognitive decline, and accelerated neurological ageing

It is mainly related to smoking

A total of 10 l of CCK-8 solution was added to each well, and the cells were incubated for 1 h in the incubator

doi: 10.1016/j.arr.2023.101978 82 KumariS.KumaranS.GoyalV.SharmaR

In addition, one of the mechanisms by which iron overload contributes to these disorders is epigenetic regulation, potentially presenting a therapeutic target and novel link between brain iron accumulation and the pathophysiology of both neurodegenerative and mental disorders