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Importantly, when astrocytes are exposed to inflammatory stimuli (e.g., TNF-/IL-1/C1q), the HK2PINK1 axis becomes up-regulated, enhancing mitophagy and reducing neurotoxic outcomes in neuronastrocyte co-culture models and in vivo

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Specifically, altered microbiota composition can disrupt dopamine metabolism and subsequently interfere with thyroid-stimulating hormone (TSH) secretion via the hypothalamicpituitary-thyroid axis, further complicating thyroid homeostasis (Xie et al., 2023)

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An in vitro study demonstrated that glycation can mask IgE proteins and decrease their availability for specific IgE antibodies, which decreases a proteins allergenicity (193)

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