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As the disease advances, ferroptosis-induced release of damage-associated molecular patterns (DAMPs), exosomal transmission, and immune evasion mechanisms further amplify neuroinflammation and cell damage, establishing a cascade of intercellular pathological propagation that accelerates neurodegeneration

222,223 Eicosapentaenoic acid, an omega-3 fatty acid found in fish oil, inhibits the expression of IL-6 and IFN- by inhibiting the phosphorylation of TGF-1 and EGFR, thereby inhibiting the nuclear translocation of NF-B

doi: 10.1172/JCI45977

Vagus nerve stimulation: a new promising therapeutic tool in inflammatory bowel disease

Mitochondrial dysfunctions in myalgic encephalomyelitis/ chronic fatigue syndrome explained by activated immuno-inflammatory, oxidative and nitrosative stress pathways

[DOI] [PubMed] [Google Scholar] 24.Rumack BH