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The inhibition of SGLT2 decreases the expression of HIF-1 in human proximal tubules under hypoxic conditions, leading to a reduction in tubular damage and interstitial fibrosis (274, 275)

Sanmartin et al., 2007) and fruit expansion (Ioannidi et al., 2009)

Importantly, continuous subcutaneous infusion of LPS showed a tendency to cause the change of glucose metabolism and the pattern of weight gain was similar to that seen when taking a high-fat diet [189, 190]