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Moderate glutathione synthetase deficiency leads to hemolytic anemia and metabolic acidosis, whereas patients with a more severe deficiency also develop 5-oxoprolinuria, recurrent bacterial infections, and progressive dysfunction of the central nervous system, including mental retardation and motor functional disturbances

Numerous studies have highlighted the therapeutic potential of glutathione in mitigating inflammation and oxidative stress, both of which are prominent features of gut dysbiosis

In addition, glutamine is shown to protect against pathogen-induced intestinal damage in vivo

Intralysosomal iron chelation protects against oxidative stress-induced cellular damage

(A) Representative images of F4/80 immunohistochemical staining of the skin of C57BL/6J mice 72 hours post-treatment

Osteoarthritis as a disease of mechanics