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The last GSH synthetic process is the one depending on the conversion of the oxidized dimer GSSG to 2 reduced GSH molecules in cells by glutathione reductase (GR), an ubiquitous enzyme of the family of disulfide reductases, in the presence of NADPH and flavin adenine dinucleotide -FAD-

Injection of ferrostatin-1 into the joints has been shown to increase collagen II expression, promote activation of the Nrf2 antioxidant system, and reduce cartilage degradation, which helps alleviate arthritis inflammation [156]

doi: 10.1016/j.mito.2021.06.010 24

Acute kidney injury model established by systemic glutathione depletion in mice

Meanwhile, mitochondrial dysfunction is closely associated with pathogenesis of NASH

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