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This is consistent with reduced lymphocyte proliferation in aged mice after high Cu treatment against those with naturally obtained serum Cu concentrations (Massie et al., 1993)

PLoS ONE 11:e0166552

Important inflammatory markers Cytokines and chemokines Various inflammatory markers play a crucial role in the pathogenesis of MASLD

doi: 10.1080/01635581.2019.1670217 97 LeeJSet al

The Mediterranean diet, rich in monounsaturated fats and polyphenols, reduces adipose inflammation by suppressing NF-B and MAPK pathways while activating AMPK (264, 265)

These effects may be mediated through the modulation of iron metabolism, the inhibition of lipid peroxidation and the enhancement of antioxidant capacity