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The significant preservation of the histological architecture of the HF in H&E and Schmorls stained sections in group III (CYP & NAC) mice may be attributed to the antiinflammatory effect of NAC, which could be owing to its ability to inhibit the activation of the proinflammatory NF-B (Smaga et al

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It is not an evidence upgrade

The liver's detoxification processes rely heavily on glutathione

In addition, in vivo, decreased occludin levels in combination with increased claudin-2 and claudin-15 36 might in synergy result in the observed increased barrier leakiness in CIA mice

Katzer K, Hill JL, McIver KB, Foster MT