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Moreover, dysregulation of the tumor suppressor, p53, combined with upregulation of anti-apoptotic genes was linked to lower apoptosis in keloids 5,6

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Schuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan , Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavali A, Zimmermann R (2012) BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER

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Of these many markers, few are soluble, including Fas ligand, granzyme B, soluble CD40 ligand, granulysin, serum high mobility group protein B1, serum lactate dehydrogenase, a-defensins 13 in the blisters, Bcl-2 expression in the dermal infiltrates, thymus and activation-regulated chemokine, and glutathione-S transferase-pi expression

Experience with host cell protein impurities in biopharmaceuticals