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In fact, a United States prospective cohort study[14] showed that 6% of patients with an acute combination medication overdose of paracetamol with antihistamines or opioids had paracetamol levels that were initially low at the 4-hour time mark but were later found to be above the 150 g/mL treatment threshold

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J Pathol 236(1):116127 Terceiro LEL et al (2023) Navigating the Blood-Brain barrier: challenges and therapeutic strategies in breast cancer brain metastases