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In synergy with IL-36Ra, IL-36 promotes the intestinal inflammation through the NF-KB pathway, which maintains the homeostasis by balancing the pro- and anti-inflammatory responses in the TME (88)

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Caco-2 cells as a model of enterocyte differentiation has been widely used in the past for drug absorption, barrier permeability and toxicological studies ( Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author

ngr D, Jensen JE, Prescot AP, Stork C, Lundy M, Cohen BM, et al

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