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10.1016/j.enzmictec.2004.07.023 Enzyme Microb

The International Federation of Gynecology and Obstetrics (FIGO) staging remains the single most important prognostic factor: five-year relative survival approaches 92% when disease is confined to the ovaries (stage I) but falls to 32% with distant metastasis (stage IV) [46, 47]

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These processes not only sustain oncogenic signaling and protect critical cellular components but also reshape the TME to counteract various therapeutic strategies, ultimately promoting treatment resistance

Moreover, TEVs may contain tumor antigens that can be presented to CD8 + T cells by LECs leading to their deletion, and thus contributing to the inhibition of tumor immunity (178) ( Figure 4C )