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Cho, [email protected] Sharifi-Rad, [email protected] This article was submitted to Oxidant Physiology, a section of the journal Frontiers in Physiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

The barrier becomes confused: one day its nourished, the next day its inflamed, and the cycle continues

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However, after receiving 3 months of treatment, when the inflammation has declined while the recurrent pain persists, the condition may be better explained by NPP ( Pre-existing infections may represent one of the potential pathogenic factors involved in NPP initiation and development

Effective design requires matching the pH activation window to the extent of joint acidification, tuning release timing through crosslink strength and diffusion channels, and enhancing cartilage affinity or cellular uptake to limit unproductive diffusion while improving deep penetration and repair efficiency