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A 2017 study found that B12 supports healthy sperm by increasing sperm count and reducing damage to DNA

A randomized, double-blind, placebo-controlled trial in 153 older adults taking the antidepressant citalopram found daily supplementation with 500 g vitamin B 12 , 2 mg of folic acid, and 25 mg of vitamin B6 for one year did not reduce the severity of depressive symptoms but increased the response to drug treatment and helped to prevent symptom relapse (112), suggesting B-vitamin supplementation might provide some benefit as an adjunct therapy

[PubMed: 19752219] 106

doi: 10.1182/blood-2009-06-189209

Skin improvements may take a few weeks to become noticeable, while enhanced immunity and overall wellness develop progressively with regular treatments

The cell needs PARP1 activation to protect genome integrity, yet too much activation can drain NAD+ pools