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Autoimmunerkrankungen , die mit Entzndungen und/oder groem oxidativen Stress einhergehen

(2015) 10:e0124599

In addition, the results indicated essential roles of GPX in controlling ROS homeostasis by regulating intracellular H 2 O 2 levels, maintaining GSH/GSSG balance, and promoting antioxidant enzyme activity

Our study found that severely elevated OxS (as a likely consequence of GSH deficiency) in the heart, liver and kidneys of old mice improved only with GlyNAC supplementation, and not with isocaloric-isonitrogenous placebo diets

Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, et al

Moreover, the prevailing reliance on animal models in the extant literature, coupled with the insufficient validation of clinical trial findings, accentuates the critical need for bridging the translational divide between preclinical insights and clinical application