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Complementing this primary mechanism, emerging evidence indicates that SFN modulates iron metabolism through upregulation of ferritin heavy chain (FTH1), potentially altering intracellular iron homeostasis to promote iron-mediated lipid peroxidation via Fenton chemistry (69, 70)

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In a study of 608 gastric bypass patients, 553 of whom remained in contact, significant weight loss was still observed at 14 years out from surgery

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