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2005;288(4):H1796801

Evidence Gaps: Most positive findings come from topical formulations or small studies

357 ParkJ

Notably, adipocyte size expansion beyond critical thresholds activates death pathways even in lean tissue by compromising phosphatidylserine-dependent clearance mechanisms

Although the mechanism by which proteasome inhibitors kill neoplastic cells is not known with certainty, it has been shown that proteasome inhibitors interfere with key steps of tumor cell regulation, leading to a block of proliferation and death of neoplastic cells both in vitro and in vivo , thus emerging as a new class of anticancer drugs

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