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Rating: 4.6444 (17 reviews)

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Description

10.1001/archpsyc.61.7.705 117 SannaM

Rheumatology 62, 25

Nedeltcheva, A

Norton, C

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Integrating the proteomic and metabolic datasets, we discovered that enzymes pivotal to cysteine biosynthesis, such as cystathionine beta-synthase (CBS) [27], and key glutathione biosynthesis genes, including glutamate-cysteine ligase catalytic subunit (GCLC) [28] and Glutamate-cysteine ligase regulatory subunit (GCLM) [29], were key downstream targets downregulated upon DDX3X inhibition (Fig