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Conclusion Multimodal therapies combining glycemic control, lipid management, mitochondrial protection, and ion channel modulation are required

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The absence of (anti-)oestrogenic effects in the present study, apart from our adaptation to the assay, might be because there were no ER ligands in the samples

[63] While children with NF1 exhibit more autism-related symptoms and behavioral problems compared to typically developing children, these are often explained by the presence of ADHD and other concurrent issues, without reaching clinically significant levels

Serum liver tests should be performed prior to therapy and at frequent intervals thereafter, especially during the first six months of valproate therapy