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SIRT1 stimulates the deacetylation and functional enhancement of PGC-1-a pivotal controller of mitochondrial biosynthesis and cellular antioxidant capacity-while p53 concurrently modulates SLC7A11 expression, a core subunit of the cystine/glutamate antiporter essential for glutathione production (117)

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[PubMed: 21730278] 127

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Using expired BAC water for reconstitution introduces potential microbial concerns independent of the peptide

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The use of MYCN-regulatable cell systems only moderately affected treatment sensitivity

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